Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL
نویسندگان
چکیده
منابع مشابه
Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries.
In mice lacking glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1), the LPL secreted by adipocytes and myocytes remains bound to heparan sulfate proteoglycans (HSPGs) on all cells within tissues. That observation raises a perplexing issue: Why isn't the freshly secreted LPL in wild-type mice captured by the same HSPGs, thereby preventing LPL from reaching...
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Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG. Accordingly, apoC3 knockout (apoC3(-/-)) mice are hypotriglyceridemic. In the present study, we attempted to elucidate the mechanism(s) under...
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Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding. To probe this, we used oil-drop tensiometry to characterize binding of six apoC-III variants to lipid/water interfaces. This technique monitors the dependence of lipid binding on su...
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Remnants produced from rat chylomicrons in hepatectomized rats or from human chylomicrons by incubation in postheparin plasma contained much less C-apolipoproteins, but more lysophosphatidylcholine than the parent chylomicrons. A phospholipid-triglyceride emulsion absorbed C-apolipoproteins during incubation in serum, yet not in postheparin plasma, which led to lipid-hydrolysis and increased in...
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taining Lipoproteins in Obese Girls, Piers R. Blackett, Robin Germany, Boureima Sambo, and Petar Alaupovic, ( Department of Pediatrics, 2 University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; 3 Medical Research Foundation, Oklahoma City, OK 73109; * address correspondence to this author at: Children’s Hospital of Oklahoma, Room 2426, 940 NE 13th St., Oklahoma City, OK 73104; f...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2017
ISSN: 0022-2275
DOI: 10.1194/jlr.m078220